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Inhibition of long non-coding RNA UCA1 by CRISPR/Cas9 attenuated malignant phenotypes of bladder cancer

CRISPR/Cas9 is a novel and effective genome editing technique, but its application is not widely expanded to manipulate long non-coding RNA (lncRNA) expression. The lncRNA urothelial carcinoma-associated 1 (UCA1) is upregulated in bladder cancer and promotes the progression of bladder cancer. Here,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhen, Shuai, Hua, Ling, Liu, Yun-Hui, Sun, Xiao-Min, Jiang, Meng-Meng, Chen, Wei, Zhao, Le, Li, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354759/
https://ncbi.nlm.nih.gov/pubmed/28038452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14176
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