Integrated analysis of promoter mutation, methylation and expression of AKT1 gene in Chinese breast cancer patients

BACKGROUND: As downstream mediators of PI3K /PTEN /AKT /mTORC1 pathway, the AKT isoforms play critical roles in tumorgenesis. Although the pleiotropic effects of AKT1 in breast cancer have been reported, the genetic and epigenetic characteristics of AKT1 promoter region in breast cancer remains to b...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Heng, Jianfu, Guo, Xinwu, Wu, Wenhan, Wang, Yue, Li, Guoli, Chen, Ming, Peng, Limin, Wang, Shouman, Dai, Lizhong, Tang, Lili, Wang, Jun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354459/
https://ncbi.nlm.nih.gov/pubmed/28301567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174022
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