Integrated analysis of promoter mutation, methylation and expression of AKT1 gene in Chinese breast cancer patients

BACKGROUND: As downstream mediators of PI3K /PTEN /AKT /mTORC1 pathway, the AKT isoforms play critical roles in tumorgenesis. Although the pleiotropic effects of AKT1 in breast cancer have been reported, the genetic and epigenetic characteristics of AKT1 promoter region in breast cancer remains to b...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Heng, Jianfu, Guo, Xinwu, Wu, Wenhan, Wang, Yue, Li, Guoli, Chen, Ming, Peng, Limin, Wang, Shouman, Dai, Lizhong, Tang, Lili, Wang, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354459/
https://ncbi.nlm.nih.gov/pubmed/28301567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174022
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