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Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins

Cyclin A1 (Ccna1), a member of the mammalian A type cyclins, is most abundantly expressed in spermatocytes and is essential for spermatogenesis in the mouse. Ccna1- deficient spermatocytes arrest at late meiotic prophase and undergo apoptosis. To further delineate the mechanisms and key factors invo...

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發表在:PLoS One
Main Authors: Panigrahi, Sunil K., Manterola, Marcia, Wolgemuth, Debra J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354389/
https://ncbi.nlm.nih.gov/pubmed/28301569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173926
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