Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders that exist on a symptomological spectrum and share both genetic underpinnings and pathophysiological hallmarks. Functional abnormality of TAR DNA-binding protein 43 (TDP-43)...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Krug, Lisa, Chatterjee, Nabanita, Borges-Monroy, Rebeca, Hearn, Stephen, Liao, Wen-Wei, Morrill, Kathleen, Prazak, Lisa, Rozhkov, Nikolay, Theodorou, Delphine, Hammell, Molly, Dubnau, Josh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354250/
https://ncbi.nlm.nih.gov/pubmed/28301478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006635
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