A novel benzo-heterocyclic amine derivative N30 inhibits influenza virus replication by depression of Inosine-5’-Monophospate Dehydrogenase activity

BACKGROUD: Influenza virus is still a huge threat to the world-wide public health. Host inosine-5’- monophosphate dehydrogenase (IMPDH) involved in the synthesis of guanine nucleotides, is known to be a potential target to inhibit the replication of viruses. Herein, we evaluated antiviral activity o...

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Enregistré dans:
Détails bibliographiques
Publié dans:Virol J
Auteurs principaux: Hu, Jin, Ma, Linlin, Wang, Huiqiang, Yan, Haiyan, Zhang, Dajun, Li, Zhuorong, Jiang, Jiandong, Li, Yuhuan
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353780/
https://ncbi.nlm.nih.gov/pubmed/28298229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-017-0724-6
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