Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19

The transport of peroxisomal membrane proteins (PMPs) requires the soluble PEX19 protein as chaperone and import receptor. Recognition of cargo PMPs by the C-terminal domain (CTD) of PEX19 is required for peroxisome biogenesis in vivo. Farnesylation at a C-terminal CaaX motif in PEX19 enhances the P...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Emmanouilidis, Leonidas, Schütz, Ulrike, Tripsianes, Konstantinos, Madl, Tobias, Radke, Juliane, Rucktäschel, Robert, Wilmanns, Matthias, Schliebs, Wolfgang, Erdmann, Ralf, Sattler, Michael
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353646/
https://ncbi.nlm.nih.gov/pubmed/28281558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14635
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