The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy

In young rats, ischemic preconditioning (IPC), which consists of 4 cycles of ischemia and reperfusion alleviated kidney injury caused by 40-min ischemia. However,old rats lost their ability to protect the ischemic kidney by IPC. A similar aged phenotype was demonstrated in 6-month-old OXYS rats havi...

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Publicado en:Sci Rep
Autores principales: Jankauskas, Stanislovas S., Pevzner, Irina B., Andrianova, Nadezda V., Zorova, Ljubava D., Popkov, Vasily A., Silachev, Denis N., Kolosova, Nataliya G., Plotnikov, Egor Y., Zorov, Dmitry B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353572/
https://ncbi.nlm.nih.gov/pubmed/28294175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44430
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