Extracellular α-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving β-arrestin signal intact

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. The presence of α-synuclein (α-Syn)-positive intracytoplasmic inclusions, known as Lewy bodies, is the cytopathological hallmark of PD. Increasing bodies of evidence suggest that cell-to-cell transmission of α-Syn plays a...

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Vydáno v:Sci Rep
Hlavní autoři: Zhang, Lifang, Okada, Taro, Badawy, Shaymaa Mohamed Mohamed, Hirai, Chihoko, Kajimoto, Taketoshi, Nakamura, Shun-ichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353548/
https://ncbi.nlm.nih.gov/pubmed/28300069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44248
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