Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer

Hypoxic microenvironment is critically involved in the response of non-small cell lung cancer (NSCLC) to chemotherapy, the mechanisms of which remain largely unknown. Here, we found that NSCLC patients exhibited increased chemotherapeutic resistance when complicated by chronic obstructive pulmonary...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Mingxing, Li, Guoyin, Yang, Zhiwei, Wang, Lei, Zhang, Lei, Wang, Ting, Zhang, Yimeng, Zhang, Shengli, Han, Yong, Jia, Lintao
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352384/
https://ncbi.nlm.nih.gov/pubmed/28042952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14097
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