MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling

Androgen deprivation therapy (ADT) is the main therapeutic option for advanced prostate cancer (PCa). After initial regression, most tumors develop into castration-resistant PCa (CRPC). Previously, we found the Mediator complex subunit MED15 to be overexpressed in CRPC and to correlate with clinical...

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Publicado en:Oncotarget
Main Authors: Offermann, Anne, Vlasic, Ignacija, Syring, Isabella, Vogel, Wenzel, Ruiz, Christian, Zellweger, Tobias, Rentsch, Cyrill A, Hagedorn, Susanne, Behrends, Jochen, Nowak, Michael, Merseburger, Axel, Bubendorf, Lukas, Kirfel, Jutta, Duensing, Stefan, Adler, David, Perner, Sven
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352374/
https://ncbi.nlm.nih.gov/pubmed/27974704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13860
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