Kras mutations increase telomerase activity and targeting telomerase is a promising therapeutic strategy for Kras-mutant NSCLC

As shortened telomeres inhibit tumor formation and prolong life span in a Kras(G12D) mouse lung cancer model, we investigated the implications of telomerase in Kras-mutant NSCLC. We found that Kras mutations increased TERT (telomerase reverse transcriptase) mRNA expression and telomerase activity an...

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Udgivet i:Oncotarget
Main Authors: Liu, Weiran, Yin, Yuesong, Wang, Jun, Shi, Bowen, Zhang, Lianmin, Qian, Dong, Li, Chenguang, Zhang, Hua, Wang, Shengguang, Zhu, Jinfang, Gao, Liuwei, Zhang, Qiang, Jia, Bin, Hao, Ligang, Wang, Changli, Zhang, Bin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352098/
https://ncbi.nlm.nih.gov/pubmed/27329725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10162
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