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An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional Screening

[Image: see text] DNA-encoded synthesis is rekindling interest in combinatorial compound libraries for drug discovery and in technology for automated and quantitative library screening. Here, we disclose a microfluidic circuit that enables functional screens of DNA-encoded compound beads. The device...

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Bibliographic Details
Published in:ACS Comb Sci
Main Authors: MacConnell, Andrew B., Price, Alexander K., Paegel, Brian M.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2017
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350604/
https://ncbi.nlm.nih.gov/pubmed/28199790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.6b00192
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