Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation

Dendritic cells (DCs) promote either tolerogenic or immunogenic T cell responses, the latter upon sensing microbes. Using an in vitro system, we analyzed transcriptional determinants that enable mature DCs to direct these opposing T cell outcomes. In the absence of microbial products, the transcript...

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Pubblicato in:J Cell Biol
Autori principali: Vander Lugt, Bryan, Riddell, Jeremy, Khan, Aly A., Hackney, Jason A., Lesch, Justin, DeVoss, Jason, Weirauch, Matthew T., Singh, Harinder, Mellman, Ira
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350508/
https://ncbi.nlm.nih.gov/pubmed/28130292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201512012
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