Bicarbonate‐rich fluid secretion predicted by a computational model of guinea‐pig pancreatic duct epithelium

KEY POINTS: The ductal system of the pancreas secretes large volumes of alkaline fluid containing HCO(3) (−) concentrations as high as 140 mm during hormonal stimulation. A computational model has been constructed to explore the underlying ion transport mechanisms. Parameters were estimated by fitti...

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Udgivet i:J Physiol
Main Authors: Yamaguchi, Makoto, Steward, Martin C., Smallbone, Kieran, Sohma, Yoshiro, Yamamoto, Akiko, Ko, Shigeru B. H., Kondo, Takaharu, Ishiguro, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Computational Physiology and Modelling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350461/
https://ncbi.nlm.nih.gov/pubmed/27995646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273306
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