Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium Overload

Intracellular Ca(2+) mishandling is an underlying mechanism in hypoxia/reoxygenation (H/R) injury that results in mitochondrial dysfunction and cardiomyocytes death. These events are mediated by mitochondrial Ca(2+) (mCa(2+)) overload that is facilitated by the mitochondrial calcium uniporter (MCU)...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Oropeza-Almazán, Yuriana, Vázquez-Garza, Eduardo, Chapoy-Villanueva, Héctor, Torre-Amione, Guillermo, García-Rivas, Gerardo
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350333/
https://ncbi.nlm.nih.gov/pubmed/28337252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5750897
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