Structural Basis of Eco1-Mediated Cohesin Acetylation

Sister-chromatid cohesion is established by Eco1-mediated acetylation on two conserved tandem lysines in the cohesin Smc3 subunit. However, the molecular basis of Eco1 substrate recognition and acetylation in cohesion is not fully understood. Here, we discover and rationalize the substrate specifici...

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Publicado no:Sci Rep
Main Authors: Chao, William C. H., Wade, Benjamin O., Bouchoux, Céline, Jones, Andrew W., Purkiss, Andrew G., Federico, Stefania, O’Reilly, Nicola, Snijders, Ambrosius P., Uhlmann, Frank, Singleton, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349539/
https://ncbi.nlm.nih.gov/pubmed/28290497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44313
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