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The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling

The importance of primary cilia in human health is underscored by the link between ciliary dysfunction and a group of primarily recessive genetic disorders with overlapping clinical features, now known as ciliopathies. Many of the proteins encoded by ciliopathy-associated genes are components of a h...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Goetz, Sarah C., Bangs, Fiona, Barrington, Chloe L., Katsanis, Nicholas, Anderson, Kathryn V.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349470/
https://ncbi.nlm.nih.gov/pubmed/28291807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173399
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