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Rewiring yeast acetate metabolism through MPC1 loss of function leads to mitochondrial damage and decreases chronological lifespan
During growth on fermentable substrates, such as glucose, pyruvate, which is the end-product of glycolysis, can be used to generate acetyl-CoA in the cytosol via acetaldehyde and acetate, or in mitochondria by direct oxidative decarboxylation. In the latter case, the mitochondrial pyruvate carrier (...
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| Published in: | Microb Cell |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Shared Science Publishers OG
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5349135/ https://ncbi.nlm.nih.gov/pubmed/28357219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2014.12.178 |
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