Inhibition of Aβ(42) oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs

The formation of small Aβ(42) oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinositol binding clathrin assembly protein (PICALM), red...

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Bibliografiske detaljer
Udgivet i:Microb Cell
Main Authors: Park, Sei-Kyoung, Ratia, Kiira, Ba, Mariam, Valencik, Maria, Liebman, Susan W.
Format: Artigo
Sprog:Inglês
Udgivet: Shared Science Publishers OG 2016
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349104/
https://ncbi.nlm.nih.gov/pubmed/28357335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2016.02.476
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