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Inhibition of Aβ(42) oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs
The formation of small Aβ(42) oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinositol binding clathrin assembly protein (PICALM), red...
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| Publicado no: | Microb Cell |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Shared Science Publishers OG
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5349104/ https://ncbi.nlm.nih.gov/pubmed/28357335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2016.02.476 |
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