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The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression
Pygo2 acts as a co-activator of Wnt signaling in a nuclear complex with ß-catenin/BCL9/BCL9-2 to increase target gene transcription. Previous studies showed that Pygo2 is upregulated in murine intestinal tumors and human colon cancer, but is apparently dispensable for normal intestinal homeostasis....
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| Publicado en: | Oncotarget |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5348345/ https://ncbi.nlm.nih.gov/pubmed/27811361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13016 |
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