A Hexasaccharide Containing Rare 2‐O‐Sulfate‐Glucuronic Acid Residues Selectively Activates Heparin Cofactor II

Glycosaminoglycan (GAG) sequences that selectively target heparin cofactor II (HCII), a key serpin present in human plasma, remain unknown. Using a computational strategy on a library of 46 656 heparan sulfate hexasaccharides we identified a rare sequence consisting of consecutive glucuronic acid 2‐...

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Bibliografiska uppgifter
I publikationen:Angew Chem Int Ed Engl
Huvudupphovsmän: Sankarayanarayanan, Nehru Viji, Strebel, Tamara R., Boothello, Rio S., Sheerin, Kevin, Raghuraman, Arjun, Sallas, Florence, Mosier, Philip D., Watermeyer, Nicholas D., Oscarson, Stefan, Desai, Umesh R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
Ämnen:
Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347859/
https://ncbi.nlm.nih.gov/pubmed/28124818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201609541
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