Protein Surface Mimetics: Understanding How Ruthenium Tris(Bipyridines) Interact with Proteins

Protein surface mimetics achieve high‐affinity binding by exploiting a scaffold to project binding groups over a large area of solvent‐exposed protein surface to make multiple cooperative noncovalent interactions. Such recognition is a prerequisite for competitive/orthosteric inhibition of protein–p...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Hewitt, Sarah H., Filby, Maria H., Hayes, Ed, Kuhn, Lars T., Kalverda, Arnout P., Webb, Michael E., Wilson, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347857/
https://ncbi.nlm.nih.gov/pubmed/27860106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600552
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