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CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells
Triplebodies are antibody-derived recombinant proteins carrying 3 antigen-binding domains in a single polypeptide chain. Triplebody SPM-1 was designed for lysis of CD19-bearing malignant B-lymphoid cells through the engagement of CD16-expressing cytolytic effectors, including NK and γδ T cells. SPM-...
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Udgivet i: | Oncotarget |
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Main Authors: | , , , , , , , , , , , , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Impact Journals LLC
2016
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5347777/ https://ncbi.nlm.nih.gov/pubmed/27825135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13110 |
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