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CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells

Triplebodies are antibody-derived recombinant proteins carrying 3 antigen-binding domains in a single polypeptide chain. Triplebody SPM-1 was designed for lysis of CD19-bearing malignant B-lymphoid cells through the engagement of CD16-expressing cytolytic effectors, including NK and γδ T cells. SPM-...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Schiller, Christian B., Braciak, Todd A., Fenn, Nadja C., Seidel, Ursula J. E., Roskopf, Claudia C., Wildenhain, Sarah, Honegger, Annemarie, Schubert, Ingo A., Schele, Alexandra, Lämmermann, Kerstin, Fey, Georg H., Jacob, Uwe, Lang, Peter, Hopfner, Karl-Peter, Oduncu, Fuat S.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347777/
https://ncbi.nlm.nih.gov/pubmed/27825135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13110
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