Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models

Disulfiram (DS), a clinically used drug to control alcoholism, has displayed promising anti-cancer activity against a wide range of tumors. Here, we demonstrated that DS/copper (Cu) complex effectively eliminated adult B-ALL cells in vitro and in vivo in patient-derived xenograft (PDX) humanized mou...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Deng, Manman, Jiang, Zhiwu, Li, Yin, Zhou, Yong, Li, Jie, Wang, Xiangmeng, Yao, Yao, Wang, Weiguang, Li, Peng, Xu, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347685/
https://ncbi.nlm.nih.gov/pubmed/27203215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9413
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