Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization

[Image: see text] Protein homodimers play important roles in physiological and pathological processes, including cancer invasion and metastasis. Recently, MMP-9 natural homodimerization via the PEX domain has been correlated with high migration rates of aggressive cancer cells. Here we propose that...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Nuti, Elisa, Rosalia, Lea, Cuffaro, Doretta, Camodeca, Caterina, Giacomelli, Chiara, Da Pozzo, Eleonora, Tuccinardi, Tiziano, Costa, Barbara, Antoni, Claudia, Vera, Laura, Ciccone, Lidia, Orlandini, Elisabetta, Nencetti, Susanna, Dive, Vincent, Martini, Claudia, Stura, Enrico A., Rossello, Armando
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346986/
https://ncbi.nlm.nih.gov/pubmed/28337319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00446
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