A Phase I study to determine the pharmacokinetic profile, safety and tolerability of sildenafil (Revatio(®)) in cardiac surgery: the REVAKI‐1 study

AIMS: Acute kidney injury (AKI) is a common and severe complication of cardiac surgery. There is no effective prevention or treatment. Sildenafil citrate (Revatio(®), Pfizer Inc.), a phosphodiesterase type 5 inhibitor, prevents post cardiac surgery AKI in pre‐clinical studies, however its use is con...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Ring, Arne, Morris, Tom, Wozniak, Marcin, Sullo, Nikol, Dott, William, Verheyden, Veerle, Kumar, Tracy, Brunskill, Nigel, Vaja, Rakesh, Murphy, Gavin J.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Clinical Trials
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346869/
https://ncbi.nlm.nih.gov/pubmed/27779776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13162
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