Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms

BACKGROUND: Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G6PD). Fifteen PQ-thiazolidinone derivatives, synthesized through one-post re...

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Dettagli Bibliografici
Pubblicato in:Malar J
Autori principali: Aguiar, Anna Caroline C., Figueiredo, Flávio Jr. B., Neuenfeldt, Patrícia D., Katsuragawa, Tony H., Drawanz, Bruna B., Cunico, Wilson, Sinnis, Photini, Zavala, Fidel, Krettli, Antoniana U.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345155/
https://ncbi.nlm.nih.gov/pubmed/28279180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-017-1755-6
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