DPP-4 Inhibitor and Estrogen Share Similar Efficacy Against Cardiac Ischemic-Reperfusion Injury in Obese-Insulin Resistant and Estrogen-Deprived Female Rats

Estrogen deprivation aggravates cardiac injury after myocardial ischemia and reperfusion (I/R) injury. Although either estrogen or the dipeptidyl peptidase-4 (DPP-4) inhibitor, vildagliptin, reduces myocardial damage following cardiac I/R, their effects on the heart in obese-insulin resistant and es...

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Pubblicato in:Sci Rep
Autori principali: Sivasinprasasn, Sivaporn, Tanajak, Pongpan, Pongkan, Wanpitak, Pratchayasakul, Wasana, Chattipakorn, Siriporn C., Chattipakorn, Nipon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345038/
https://ncbi.nlm.nih.gov/pubmed/28281660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44306
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