PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

Protein post-translation modification plays an important role in regulating DNA repair; however, the role of arginine methylation in this process is poorly understood. Here we identify the arginine methyltransferase PRMT5 as a key regulator of homologous recombination (HR)-mediated double-strand bre...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Clarke, Thomas L., Sanchez-Bailon, Maria Pilar, Chiang, Kelly, Reynolds, John J., Herrero-Ruiz, Joaquin, Bandeiras, Tiago M., Matias, Pedro M., Maslen, Sarah L., Skehel, J. Mark, Stewart, Grant S., Davies, Clare C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344794/
https://ncbi.nlm.nih.gov/pubmed/28238654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.019
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