Association of Polymorphisms in FCGR2A and FCGR3A With Degree of Trastuzumab Benefit in the Adjuvant Treatment of ERBB2/HER2–Positive Breast Cancer: Analysis of the NSABP B-31 Trial

IMPORTANCE: Preclinical models and studies in the metastatic and neoadjuvant settings suggest that single nucleotide polymorphisms in FCGR3A and FCGR2A may be associated with differential response to trastuzumab in the treatment of ERBB2/HER2–positive breast cancer, by modulating antibody-dependent...

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Udgivet i:JAMA Oncol
Main Authors: Gavin, Patrick G., Song, Nan, Kim, S. Rim, Lipchik, Corey, Johnson, Nicole L., Bandos, Hanna, Finnigan, Melanie, Rastogi, Priya, Fehrenbacher, Louis, Mamounas, Eleftherios P., Swain, Sandra M., Wickerham, D. Lawrence, Geyer, Charles E., Jeong, Jong-Hyeon, Costantino, Joseph P., Wolmark, Norman, Paik, Soonmyung, Pogue-Geile, Kay L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344747/
https://ncbi.nlm.nih.gov/pubmed/27812689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2016.4884
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