Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species

BACKGROUND: Interleukin-32 (IL-32) is expressed in lesions of patients with American Tegumentary Leishmaniasis (ATL), but its precise role in the disease remains unknown. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, silencing and overexpression of IL-32 was performed in THP-1-derived macrop...

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Dettagli Bibliografici
Pubblicato in:PLoS Negl Trop Dis
Autori principali: dos Santos, Jéssica Cristina, Heinhuis, Bas, Gomes, Rodrigo Saar, Damen, Michelle S. M. A., Real, Fernando, Mortara, Renato A., Keating, Samuel T., Dinarello, Charles A., Joosten, Leo A. B., Ribeiro-Dias, Fátima
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344527/
https://ncbi.nlm.nih.gov/pubmed/28241012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005413
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