Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice

BACKGROUND AND AIMS: A high serum level of saturated free fatty acids (FFAs) is associated with the development of nonalcoholic fatty liver disease (NAFLD). X-box binding protein-1 (XBP-1) is activated by FFA treatment upon splicing. XBP-1 is a transcription factor induced by the endoplasmic reticul...

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Publicado en:PLoS One
Autores principales: Takahara, Ikuko, Akazawa, Yuko, Tabuchi, Maiko, Matsuda, Katsuya, Miyaaki, Hisamitsu, Kido, Youko, Kanda, Yasuko, Taura, Naota, Ohnita, Ken, Takeshima, Fuminao, Sakai, Yusuke, Eguchi, Susumu, Nakashima, Masahiro, Nakao, Kazuhiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344317/
https://ncbi.nlm.nih.gov/pubmed/28278289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170591
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