Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer

Cetuximab plus chemotherapy for advanced gastric cancer (GC) shows an active result in phase 2 trials. Unfortunately, Combination of cetuximab does not provide enough benefit to chemotherapy alone in phase 3 trials. Studies have demonstrated that berberine can suppress the activation of EGFR in tumo...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Wang, Junxiong, Yang, Shuo, Cai, Xiqiang, Dong, Jiaqiang, Chen, Zhangqian, Wang, Rui, Zhang, Song, Cao, Haichao, Lu, Di, Jin, Tong, Nie, Yongzhan, Hao, Jianyu, Fan, Daiming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342797/
https://ncbi.nlm.nih.gov/pubmed/27738318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12589
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