Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas

Trans-resveratrol suppresses glioblastoma growth in vitro, but its effects on intracranial glioblastomas remain untested. Resveratrol crosses the blood–brain barrier, and lumbar puncture (LP) greatly increases its bioavailability in rat brains; therefore, we investigated the effectiveness of LP-admi...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Xue, Song, Xiao-Hong, Shu, Lin, Sha, Jie, Bian, Li-Li, Wang, Jia-Yao, Gu, Shun, Shi, Pei-Nan, Li, Mo-Li, Wu, Qian, Wang, Xiao-Yan, Chen, Qing-You, Kong, Peng, Zhang, Hong, Li, Jia, Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342778/
https://ncbi.nlm.nih.gov/pubmed/27716625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12414
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