Extrachromosomal HPV-16 LCR transcriptional activation by HDACi opposed by cellular differentiation and DNA integration

Histone deacetylase inhibitors (HDACi) have been shown to render HPV-carrying cells susceptible to intrinsic and extrinsic apoptotic signals. As such, these epigenetic drugs have entered clinical trials in the effort to treat cervical cancer. Here, we studied the effect of common HDACi, with an emph...

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Publicat a:Oncotarget
Autors principals: Bojilova, Ekaterina Dimitrova, Weyn, Christine, Antoine, Marie-Hélène, Fontaine, Véronique
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342758/
https://ncbi.nlm.nih.gov/pubmed/27705914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12263
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