The PI3K/mTOR dual inhibitor BEZ235 suppresses proliferation and migration and reverses multidrug resistance in acute myeloid leukemia

Aberrant activation of the PI3K/Akt/mTOR pathway contributes to the proliferation of malignant cells, and may confer resistance to chemotherapy in various malignancies, including acute myeloid leukemia (AML). Chemoresistance is the major reason for relapse in AML. RAD001 (everolimus) has been used a...

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Foilsithe in:Acta Pharmacol Sin
Main Authors: Deng, Lan, Jiang, Ling, Lin, Xiang-hua, Tseng, Kuo-Fu, Liu, Yuan, Zhang, Xing, Dong, Rui-hong, Lu, Zhi-gang, Wang, Xiu-ju
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342661/
https://ncbi.nlm.nih.gov/pubmed/28042875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.121
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