Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells

The chromosomal translocation t(14;18) in follicular lymphoma (FL) is a primary oncogenic event resulting in BCL-2 over-expression. This study investigates activity of the BH3 mimetic venetoclax (ABT-199), which targets BCL-2, and mechanisms of acquired resistance in FL. The sensitivity of FL cells...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bodo, Juraj, Zhao, Xiaoxian, Durkin, Lisa, Souers, Andrew J., Phillips, Darren C., Smith, Mitchell R., Hsi, Eric D.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342530/
https://ncbi.nlm.nih.gov/pubmed/27661108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12132
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