Integrin β3 and CD44 levels determine the effects of the OPN-a splicing variant on lung cancer cell growth

Osteopontin (OPN), a phosphorylated glycoprotein, is frequently overexpressed in cancer. Among the three OPN isoforms, OPN-a is the most highly expressed in lung cancer cell lines and lung tumors. Overexpression of OPN-a greatly reduced CL1-5 lung adenocarcinoma cell growth, but had no effect on gro...

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Pubblicato in:Oncotarget
Autori principali: Sun, Shih-Jung, Wu, Chun-Chi, Sheu, Gwo-Tarng, Chang, Hui-Yi, Chen, Mei-Yu, Lin, Yu-Ying, Chuang, Cheng-Yen, Hsu, Shih-Lan, Chang, Jinghua Tsai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342437/
https://ncbi.nlm.nih.gov/pubmed/27487131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10865
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