Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling

The overall survival remains undesirable in clinical glioma treatment. Inhibition of DNA-PKcs activity by its inhibitors suppresses tumor growth and enhances chemosensitivity of several tumors to chemotherapy. However, whether DNA-PKcs could be a potential target in glioma therapy remains unknown. I...

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Udgivet i:Oncotarget
Main Authors: Lan, Tian, Zhao, Zitong, Qu, Yanming, Zhang, Mingshan, Wang, Haoran, Zhang, Zhihua, Zhou, Wei, Fan, Xinyi, Yu, Chunjiang, Zhan, Qimin, Song, Yongmei
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342436/
https://ncbi.nlm.nih.gov/pubmed/27487130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10864
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