Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation

The FoxA family of pioneer transcription factors regulates hepatitis B virus (HBV) transcription, and hence viral replication. Hepatocyte-specific FoxA-deficiency in the HBV transgenic mouse model of chronic infection prevents the transcription of the viral DNA genome as a result of the failure of t...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: McFadden, Vanessa C., Shalaby, Rasha E., Iram, Saira, Oropeza, Claudia E., Landolfi, Jennifer A., Lyubimov, Alexander V., Maienschein-Cline, Mark, Green, Stefan J., Kaestner, Klaus H., McLachlan, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342274/
https://ncbi.nlm.nih.gov/pubmed/28235042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006239
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