NOX4 downregulation leads to senescence of human vascular smooth muscle cells

Senescence is a stress response characterized by an irreversible growth arrest and alterations in certain cell functions. It is believed that both double-strand DNA breaks (DSB) and increased ROS level are the main culprit of senescence. Excessive ROS production is also particularly important in the...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Przybylska, Dorota, Janiszewska, Dorota, Goździk, Aleksandra, Bielak-Zmijewska, Anna, Sunderland, Piotr, Sikora, Ewa, Mosieniak, Grażyna
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341811/
https://ncbi.nlm.nih.gov/pubmed/27655718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12079
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