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Time‐dependent activation of prostacyclin and nitric oxide pathways during continuous i.v. infusion of serelaxin (recombinant human H2 relaxin)
BACKGROUND AND PURPOSE: In the RELAX‐AHF trial, a 48 h i.v. serelaxin infusion reduced systemic vascular resistance in patients with acute heart failure. Consistent with preclinical studies, serelaxin augments endothelial vasodilator function in rat mesenteric arteries. Little is known about the con...
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| Udgivet i: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341243/ https://ncbi.nlm.nih.gov/pubmed/26660642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13404 |
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