The effects of Y-27632 on pial microvessels during global brain ischemia and reperfusion in rabbits

BACKGROUND: Global brain ischemia-reperfusion during propofol anesthesia provokes persistent cerebral pial constriction. Constriction is likely mediated by Rho-kinase. Cerebral vasoconstriction possibly exacerbates ischemic brain injury. Because Y-27632 is a potent Rho-kinase inhibitor, it should be...

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Bibliographic Details
Published in:BMC Anesthesiol
Main Authors: Shintani, Noriyuki, Ishiyama, Tadahiko, Kotoda, Masakazu, Asano, Nobumasa, Sessler, Daniel I., Matsukawa, Takashi
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341179/
https://ncbi.nlm.nih.gov/pubmed/28270098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12871-017-0331-5
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