Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity

TAM receptors (Tyro-3, Axl, and Mertk) are a family of three homologous type I receptor tyrosine kinases that are implicated in several human malignancies. Overexpression of TAMs and their major ligand Growth arrest-specific factor 6 (Gas6) is associated with more aggressive staging of cancers, poor...

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Опубликовано в: :Sci Rep
Главные авторы: Kimani, Stanley G., Kumar, Sushil, Bansal, Nitu, Singh, Kamalendra, Kholodovych, Vladyslav, Comollo, Thomas, Peng, Youyi, Kotenko, Sergei V., Sarafianos, Stefan G., Bertino, Joseph R., Welsh, William J., Birge, Raymond B.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341070/
https://ncbi.nlm.nih.gov/pubmed/28272423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43908
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