Hypoxic preconditioning of human cardiosphere-derived cell sheets enhances cellular functions via activation of the PI3K/Akt/mTOR/HIF-1α pathway

Cell sheet technology is a promising therapeutic strategy for the treatment of ischemic diseases such as myocardial infarction. We recently developed a novel protocol, termed “hypoxic preconditioning,” capable of augmenting the therapeutic efficacy of cell sheets. Following this protocol, the pro-an...

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Veröffentlicht in:Am J Transl Res
Hauptverfasser: Tanaka, Yuya, Hosoyama, Tohru, Mikamo, Akihito, Kurazumi, Hiroshi, Nishimoto, Arata, Ueno, Koji, Shirasawa, Bungo, Hamano, Kimikazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340701/
https://ncbi.nlm.nih.gov/pubmed/28337294
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