DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells

Wnt signaling plays an important role in breast carcinogenesis. DAPPER2 (DACT2) functions as an inhibitor of canonical Wnt signaling and plays distinct roles in different cell contexts, with its role in breast tumorigenesis unclear. We investigated DACT2 expression in breast cancer cell lines and pr...

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Pubblicato in:Oncotarget
Autori principali: Xiang, Tingxiu, Fan, Yichao, Li, Chunhong, Li, Lili, Ying, Ying, Mu, Junhao, Peng, Weiyan, Feng, Yixiao, Oberst, Michael, Kelly, Kathleen, Ren, Guosheng, Tao, Qian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340116/
https://ncbi.nlm.nih.gov/pubmed/27708215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12341
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