The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia

The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the mitochondrial electron transport chain. This gene has recently been proposed to be involved in oxygen sensing because mutations that cause loss of its function produce hereditary famil...

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Bibliographische Detailangaben
Hauptverfasser: Piruat, José I., Pintado, C. Oscar, Ortega-Sáenz, Patricia, Roche, Marta, López-Barneo, José
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC533988/
https://ncbi.nlm.nih.gov/pubmed/15572694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10933-10940.2004
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