The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis

MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response elemen...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Wang, Fang, Song, Wei, Zhao, Hongmei, Ma, Yanni, Li, Yuxia, Zhai, Di, Pi, Jingnan, Si, Yanmin, Xu, Jiayue, Dong, Lei, Su, Rui, Zhang, Mengmeng, Zhu, Yong, Ren, Xiaoxia, Miao, Fei, Liu, Wenjie, Li, Feng, Zhang, Junwu, He, Aibin, Shan, Ge, Hui, Jingyi, Wang, Linfang, Yu, Jia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339841/
https://ncbi.nlm.nih.gov/pubmed/28244490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.26
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