Interferon regulatory factor-1 activates autophagy to aggravate hepatic ischemia-reperfusion injury via the P38/P62 pathway in mice

Increasing evidence has linked autophagy to a detrimental role in hepatic ischemia- reperfusion (IR) injury (IRI). Here we focus on the role of interferon regulatory factor-1 (IRF-1) in regulating autophagy to aggravate hepatic IRI. We found that IRF-1 was up-regulated during hepatic IRI and was ass...

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Publicado no:Sci Rep
Main Authors: Yu, Yao, Li, Shipeng, Wang, Zhen, He, Jindan, Ding, Yijie, Zhang, Haiming, Yu, Wenli, Shi, Yiwei, Cui, Zilin, Wang, Ximo, Wang, Zhiliang, Sun, Liying, Zhang, Rongxin, Du, Hongyin, Zhu, Zhijun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339805/
https://ncbi.nlm.nih.gov/pubmed/28266555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43684
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