Polymorphic Variants of Human Protein l-Isoaspartyl Methyltransferase Affect Catalytic Activity, Aggregation, and Thermal Stability: IMPLICATIONS FOR THE ETIOLOGY OF NEUROLOGICAL DISORDERS AND COGNITIVE AGING

Protein l-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the human pcmt1 gene, catalyzes repair of abnormal l-isoaspartyl linkages in age-damaged proteins. Pcmt1 knock-out mice exhibit a profound neuropathology and die 30–60 days postnatal from an epileptic seizure. Here we express 15 repo...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Juang, Charity, Chen, Baihe, Bru, Jean-Louis, Nguyen, Katherine, Huynh, Eric, Momen, Mahsa, Kim, Jeungjin, Aswad, Dana W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339750/
https://ncbi.nlm.nih.gov/pubmed/28100787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.765222
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